Hydrochlorothiazide: The most common indicators and signs of overdose noticed in individuals are All those due to electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration ensuing from abnormal diuresis.

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Irbesartan helps prevent angiotensin II binding towards the AT1 receptor in tissues like vascular sleek muscle mass as well as the adrenal gland. Irbesartan and its Lively metabolite bind the AT1 receptor with 8500 moments much more affinity than they bind towards the AT2 receptor.

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Irbesartan blocks the vasoconstrictor and aldosterone-secreting results of angiotensin II by selectively binding into the AT1 angiotensin II receptor. There is certainly also an AT2 receptor in several tissues, but It's not necessarily involved in cardiovascular homeostasis.

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